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Although CTLA-4 and PD-1 are part of separate pathways, they exert similar inhibitory effects on effector T cell metabolism, including downregulation of AKT phosphorylation, reduced amino acid uptake, and general suppression of metabolic activity

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Relevant randomized controlled trials (RCTs) were identified from systematic searches of several major electronic databases (PubMed, EMBASE, and the Cochrane Library) up to November 2013 with the following search strategy: (L-carnitine OR carnitine) AND myocardial infarction

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bioRxiv 2020.05.12.090472