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Some methodological cautions in the use of the Tolerance questionnaire

Smokers have higher amounts of the intercellular adhesion molecules ICM-1, E-selectin, and vascular cell adhesion molecule (VCAM)-1 (34, 35)

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This condition is thought to be linked to very high doses of diacetyl, but the condition can also develop from a variety of other chemicals such as: acetaldehyde (a chemical found in marijuana smoke), metal oxide fumes (by-product of welding), formaldehyde (a chemical present in cigarettes), sulphur dioxide (a pollutant released by burning fossil fuels), ammonia, chlorine, nitrogen oxides, hydrochloric acid and sulphur mustard