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Also poorly understood is the potential relationship that may exist between hepatocyte swelling in response to amino acids, the obligatory KCC-dependent K + /Cl extrusion, the resulting reduction in [Cl ] i and glycogen synthesis via activation of the Cl -dependent enzyme glycogen synthase phosphatase (Meijer et al., 1992)

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doi: 10.3389/fimmu.2020.00710 [DOI] [PMC free article] [PubMed] [Google Scholar] 281.Wen RX, Shen H, Huang SX, et al

Clinical experience strongly supports its use for the indications below but we're working with promising preclinical data, not robust human RCTs

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