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Evidence indicates that tobacco exposure induces DNA methylation changes at CpG sites within placental tissue, resulting in overexpression of placental growth factor (PGF), vasoconstriction, and reduced placental perfusion

In the nucleus accumbens shell, aerosol from both mint/menthol and mango flavored JUULs increased the expression of TNF-, IL-1, and IL-6 following 1 and 3 months of exposure (159)

2 1.13.2 Trends in prevalence in Australian states and territories As shown in Figure 1.13.3 , the prevalence of regular smoking among Australian adults significantly declined in all states and territories between 2001 and 202223 (controlling for age and sex)