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Enzymes are crucial to metabolism because they allow organisms to drive reactions that require energy and will not occur by themselves, by coupling them to spontaneous reactions that release energy

PMID: 30915550 Seiwerth S, et al

TME-targeting theranostic agent uses NIR tracking for tumor diagnosis and surgical resection and acts as chemotherapeutic showing enhanced efficiency and minimal toxicity

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In contrast, compared to 2012.2 cells, 1919 GBM cells appeared to be metabolically dependent on the urea cycle, as suggested by the higher intracellular levels of citrulline, ornithine and arginosuccinate (Figure S4)