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The authors concluded that melatonin treatment reduced proinflammatory cytokines in tracheobronchial aspirate, serum nitrite/nitare levels, and improved outcome because of its antioxidative actions 130 ,131

Researchers may use the peptide in cell culture experiments, vascular biology studies, and preclinical research models that explore how cells respond to signaling molecules during tissue stress or repair

Notably, curcumin, a polyphenolic compound derived from turmeric, has been reported to synergize with azoles and polyenes to amplify ROS generation in Candida albicans , leading to mitochondrial damage, apoptosis, and enhanced antifungal activity (Sharma et al., 2010b

GSH depletion may play a central role in inflammatory diseases and COVID-19 pathophysiology, host immune response and disease severity and mortality

At last, the sections were colored with 3, 5-diaminobenzidine substrate, and then counterstained with hematoxylin