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The activity of GDH is regulated not just by the availability of substrate (glutamate) and co-enzyme (NADH), but also by a variety of molecules that bind to an additional regulatory site on the enzyme

A common cause of low B12 is poor absorption from the digestive tract

In comparison, the region that contains the greatest amount of variability between GST classes is contained in the alpha-2 helix on the C-terminal domain

Therefore, researchers across the world felt the need to understand how antioxidant enzymes, including seleno-GPxs, being the primary ROS detoxification machinery, modulate cellular radiosensitivity

It offers a novel approach to aging intervention by targeting telomeres, unlike traditional antioxidants that focus solely on free radicals