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Serum creatinine supplanted BUN for the assessment of kidney function in the mid-1900s and remains the most widely used laboratory test to estimate GFR 19

Pein et al

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Research published in Sleep Medicine Reviews by Obal and Krueger (2004) demonstrated that GHRH directly activates sleep-regulatory neurons in the preoptic hypothalamus, increasing NREM sleep duration and slow-wave activity independent of its effects on GH release

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