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FIGURE 6 5.3.2 Activation of NF-B by ROS promotes inflammation and protein degradation Nuclear factor-B (NF-B) is a key redox-sensitive transcription factor that regulates inflammation, cell survival, and protein catabolism in skeletal muscle (Roy et al., 2018)

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On the immune side, suppressive cell populations predominate and immunosuppressive mediators are upregulated, which weakens antitumor immune responses and compromises the durability of immunotherapy [29, 35]