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The research case for GHK-Cu is built on several pillars: demonstrated collagen stimulation (up to 70% in laboratory models), wound healing acceleration across multiple tissue types, gene expression modulation affecting approximately 4,000 human genes, anti-inflammatory activity, and antioxidant defense support
Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form
Mechanism of Action GHK-Cu exhibits a multifaceted mechanism, influencing gene expression, cellular signaling, and copper homeostasis: 2.1 Collagen and ECM Stimulation: GHK-Cu upregulates genes for collagen (types I, III, IV, VII), elastin, and glycosaminoglycans (GAGs) by modulating transcription factors like SP1 and TGF-