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The preparation was not necessarily equivalent to pure emideltide, and a mouse lifespan experiment cannot establish anti-ageing or cancer-prevention effects in humans

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This results in mitochondrial oxidative stress and dysfunction, ultimately leading to hepatocyte necrosis (Yan et al., 2018)

In addition to release of PRR ligands, hepatocyte stress and death are associated with release of pro-inflammatory cytokines, including inflammasome-mediated interleukin-1 (IL-1), which further contributes to NASH-associated hepatitis (171)