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Patients with erythema nodosum, the most common cutaneous manifestation of IBD, have tender subcutaneous nodules on the anterior extensor surfaces of the lower extremities

Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (Apr 2004)

Class I and class II HDAC inhibitors regulate expression of BDNF and HSP70

Next came the meticulous process of sewing the muscle back together, effectively encapsulating the cadaver tendon within the tear