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Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it

The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

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Recent advancements in therapeutic strategies, including bile composition modulation, microbiome interventions, and nanoparticle-based drug delivery, present promising approaches for gallstone prevention and treatment