TL: A Single Biomarker or a Part of Composite Biomarker Panel
In a related rat model, activation of p62/Nrf2 and downregulation of ROS were also observed, as evidenced by reductions in arthritis scores and pathological features (marked infiltration of inflammatory cells, synovial hyperplasia, cartilage damage and bone destruction), as well as inhibition of NFATc1 and other osteoclast activities and bone resorption regulators (CTSK and MMP-9)
A novel enzyme (the bifunctional glutathione synthetase encoded by gshF ) that possessed both -GCS and GS activities and was non-sensitive to GSH was discovered in several microorganisms, including Streptococcus agalactiae [10], Enterococcus faecalis [10], Listeria monocytogenes [11], and Streptococcus thermophiles [12]
10.1111/j.1365-2710.2004.00626.x J
MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression