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GSSG is then recycled back to GSH by glutathione reductase using NADPH

Because gluten proteins are rich in proline and glutamine, they resist complete proteolytic digestion and generate immunogenic peptides that can persist in the intestinal lumen

These mechanisms are detailed in Figure 3A

The specific mechanism may involve a compromised intestinal barrier allowing antigens from the gut microbiota to penetrate and contact IgG antibodies, forming immune complexes that circulate in the bloodstream, including to the choroid plexus of the CNS

Melanin Pathway Interaction Melanin Pathway Interaction Research suggests glutathione may interact with tyrosinase , an enzyme that plays a role in melanin production