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Indirect damage, accounting for two-thirds of the radiation-induced cell injury, means ionizing radiation is able to react with substances in cells such as water to form toxic ROS (Hall et al., 2016)

MRP proteins not only regulate GSH efflux, but also transport oxidized glutathione derivatives such as glutathione disulfide (GSSG), S-nitrosoglutathione (GS-NO) and glutathione-metal complexes, as well as other glutathione S-conjugates [77,79]

53 who reported that melatonin application alleviated the negative effects of oxidative stress and ROS production

doi: 10.1016/s0304-4165(02)00525-1