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Other Considerations: Monitoring: Regular monitoring of vitamin B12 levels, complete blood counts, and neurological function is advisable, especially in long-term use

While macrophages and other immune cells can partially clear these ROS, the excessive ROS burden surpasses the clearance capacity of immune cells, allowing residual ROS to further activate necroptosis through positive feedback mechanisms

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Further, a study assessing hormonal parameters in obese PCOS patients before and after 12 weeks of treatment (24) with myo-inositol at 2g/day in addition to folic acid (200mg) and comparing the changes to control individuals (treated with folic acid 200mg only) showed exclusively in patients treated with myo-inositol: A significant reduction in insulin levels A significant reduction in prolactin levels A significant reduction in LH levels In addition, myo-inositol had a clear impact on treated patients fertility who had much higher % of top-quality oocytes (82% vs

Bartolini et al., 2021)