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A summary including controversies and gaps in knowledge is presented in the last part of each paragraph when available, in italic font

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Microsomal GSTs are structurally distinct from the cytosolic in that they homo- and heterotrimerize rather than dimerize to form a single active site

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The lower intracellular levels of serine and glycine in cancer cells that we observed in vitro indicate a high turnover with increased consumption and usage of these amino acids in downstream biosynthetic pathways, which is supported by the enhanced SHMT2 expression in response to RT