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Arteriosclerosischaracterized by fibrous thickening and/or intimal hyalinization of renal vasculatureis believed to induce nephron ischemia, which subsequently causes global glomerulosclerosis, accompanied by tubular atrophy and fibrosis (Martin and Sheaff, 2007)
Together, they form a multi-layered defense system
Treatment of such events usually involves discontinuation of DPA (and the use of another anti-copper drug), but in more severe cases, temporary treatment with steroids is suggested to reduce the autoimmune response and clinical symptoms associated with a DPA-related adverse event [160]
FraternaleAZaraCDe AngelisMNencioniLPalamaraATRetiniMet alIntracellular redox-modulated pathways as targets for effective approaches in the treatment of viral infection
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