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Therefore, IGF-1 levels further drop and, due to the lack of negative feedback by IGF-1 on the hypothalamus, growth hormone (GH) levels increase significantly

Injections are usually administered subcutaneously (under the skin), once a month, in your vets office

In practical terms, Sermorelin may be especially relevant for patients who feel like they are not just carrying extra fat, but also dealing with lower vitality, weaker recovery, poorer sleep, slower exercise adaptation, and a gradual decline in body tone

To understand how retatrutide compares to other weight loss options, read our [retatrutide vs tirzepatide comparison](/guides/retatrutide-vs-tirzepatide-comparison).* --- ## References - [USP Chapter 797: Pharmaceutical Compounding - Sterile Preparations]( *United States Pharmacopeia*, 2023