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Furthermore, eugenol mitigates chronic inflammation by decreasing the expression of various inflammatory mediators (TNF-, NF-B, COX-2, IL-1, IL-4, IL-5, IL-6, iNOS, and NO) in both in vitro and in vivo models and also, those associated with an increase in antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase, and glutathione peroxidase) [36], A systematic review addressed the effects of eugenol on arachidonic acid (AA) derived inflammatory mediators and reported the inhibitory effect of eugenol on prostaglandin and leukotriene production and reduction of edema formation in several animal models of inflammation