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Tolerogenic peptide therapy can be further subcategorized according to the type of peptide(s) used, specifically: (1) Epitope-specific peptides: These peptides are derived from specific epitopes of self-antigens and are used to selectively target autoreactive T cells

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The significance of BBB is well understood and research over the past years has delineated various essential functions of this barrier in the regulation of ions using specific ion channels and transporters for reliable synaptic signaling by maintaining the neutral ion composition [1]