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Learn where to self-administer a B12 shot and how to do it painlessly This article was medically reviewed by Shari Forschen, NP, MA and by wikiHow staff writer, Amber Crain

Vitamin B12 is known to be excreted in human milk

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Daily intraperitoneal administration for 11 days reduced body weight gain, decreased white adipose tissue mass by approximately 35%, and reduced adipocyte size, while food intake between treated and control groups did not differ significantly

Clinical trials conducted in the early 2000s showed modest results, and the compound failed to demonstrate sufficient efficacy to support regulatory approval as a weight-loss medicine