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130 The KD may protect against obesity-induced cognitive damage 131 and confer positive effects on mood in obese participants

*Individual responses vary

Conclusions The presence or absence of transit peptide residues are the main contributing factors in subcellular localization and phylogenetic distribution of APX/GPXs

The mice exhibited progressive loss of dopaminergic neurons in the SN pars compacta , accompanied by nitrosative stress markers (nitrotyrosine, nitrosylated -synuclein) and microglial activation

In this review, we focus on the mechanistic role of the UPS in circadian clock regulation, summarize key E3 ligases and deubiquitinating enzymes implicated in clock protein turnover, and highlight the essential role of the UPS on sleep timing and overall circadian biological homeostasis