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JUULsalts e-liquid contains nicotine salts found in the tobacco leaf, rather than free-base nicotine used in most e-cigarettes and vaporizers

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At 1.75-2.00 hours after capsule ingestion, participants chewed the 2 mg nicotine gum dose (according to a standardized procedure where they chewed once every 3 seconds for 15 minutes in response to auditory cues) 29 followed immediately by another 20-minute assessment period

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They were acquired by the American Tobacco Company in 1907 with the sale of Butler & Butler