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In similar study setups, riboflavin has also been shown to prevent mitochondrial ROS production and DNA release 47

But this model had a problem: it was based on measuring static lipid levels and mitochondrial DNA content, not actual metabolic olux

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On day 2, cells were transfected with either scrambled control siRNA (Silencer Select Negative Control #1 siRNA, 4390843, Thermo Fisher Scientific) or siRNA targeting the glucocorticoid receptor (siGR) (s67066, Thermo Fisher Scientific) using Lipofectamine-mediated transfection

Imaging 14 , e012174 (2021)