It can thus affect blood rheology [361]
A particularly important function is their ability to engage in biochemical signaling with host cells, exerting effects both locally within the intestinal mucosa and systemically through immune, neural, and metabolic pathways
peaks during dose escalation, typically mild-moderate Diarrhea -- 10-20%, usually transient Constipation -- 8-15% Vomiting -- 5-15%, more frequent at higher doses Injection site reactions -- 5-10%, mild erythema and pruritus Decreased appetite -- 5-12%, related to mechanism of action Pancreatitis -- rare but monitored (as with all GLP-1/amylin agents) Gallbladder events -- cholelithiasis reported, consistent with rapid weight loss Trial data describes dose titration as central to tolerability -- the 16-week escalation protocol substantially reduced GI adverse events
Because liposomes are more soluble, you may only need a small amount
Oxidative damage to neutrophils in glutathione synthetase deficiency
