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After exposure to an irritant, the irritant will exert toxic effects on keratinocytes

Research found that chronic alcohol abuse lowers stores of this antioxidant in the liver (27)

from Seoul National University, Specialist in Family Medicine

GSH can then be synthesized de novo in a two-step ATP-requiring enzymatic process utilizing glutamate cysteine ligase (GCL) and glutathione synthetase (GS) (Figure 2) [83,87]