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In these two highly excitable tissues that can undergo rapid changes in their membrane potentials for the transport of electrical signals, creatine decreases intracellular calcium concentrations (e.g., by stimulating sarcoplasmic reticulum Ca 2+ -ATPase in skeletal muscle) and extracellular glutamate concentrations (e.g., through uptake by synaptic vesicles in the brain), and prevents the opening of the mitochondrial permeability transition pore (Bender et al

These results suggest that similar metabolic alterations occur in murine and human kidneys with TLS and that urinary GSH could be a noninvasive diagnostic biomarker to detect TLS in the kidney

Reactive oxygen species in HIV infection

The observed 28-day mortality was 42.9% (12 patients), 8 patients died in less than 72 h