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HA integrity has also been shown to critically modulate TGF--driven fibroblast differentiation, as enzymatic fragmentation suppresses -smooth muscle actin (-SMA) and collagen type I expression, emphasizing the importance of balanced HA turnover for proper ECM remodeling and scar resolution [9]

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Bei den adjuvanten Arthritisstudien war die Lsionsentwicklung nach einer einzigen NaBPC157-Anwendung betrchtlich vermindert und bei Ratten, die tglich mit NaBPC157 behandelt wurden, sogar noch mehr abgeschwcht