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This 2011 meta analysis of 86 different studies on glutamine and gut permeability, found: A significant body of evidence indicates that glutamine preserves the gut barrier function." And just as importantly the researchers found Glutamine is considered the most important nutrient for healing of leaky gut syndrome because it is the preferred fuel for enterocytes and colonocytes By contrast, Glutathiones main function is to kill free radicals and inflammatory compounds called Reactive Oxygen Species