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G.et al (2021)

While PKM2 predominantly exists as a catalytically active tetramer in normal tissues, it tends to adopt a low-activity dimeric form in CRC and various other tumor types

J Dairy Sci 82(1):2331

It has been reported that fungi do not contain orthologs of bacterial EgtA or EgtC ( egt-1 using Cys as a sulfur donor, without the need for the intermediate -glutamyl hercynylcysteine sulfoxide (Figure 4)