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In order to demonstrate that the 127 gene signature is related to regional emphysema severity within individuals and not to differences between donors and COPD patients or to differences in levels of emphysema between COPD patients, we repeated the same statistical analysis while only including the five COPD patients with emphysema and standardizing the Lm measurements within each patient core to a mean of zero and a standard deviation of one (Z-score)

19) was added at 10 M into the medium for 24 hours before harvest, with dimethyl sulfoxide or water added as vehicle control

10.1016/j.phrs.2022.106163 92 NieQ.LiM.HuangC.YuanY.LiangQ.MaX.et al (2024)

Centers for Disease Control and Prevention and the American Association of Poison Control Centers collect data on the number of deaths associated with each drug, but the figures are incomplete, making comparisons subject to question

doi: 10.1038/s41591-021-01489-1 206 JinHWangSZaalEAWangCWuHBosmaAet al