Together, our results reveal a prominent influence of the tissue immunomicrotope (Bogdan et al, 2024) on the transcriptional and functional profile of eosinophils and highlight a novel immunometabolic and regulatory activity of these innate immune cells
Hou Y, Wang L, Yi D, Ding B, Yang Z, Li J, Chen X, Qiu Y, Wu G (2013) N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling
They have discovered that polyphenols may exhibit the ability to scavenge free radicals through (1) direct reaction with reactive oxygen species (ROS), (2) enhanced dismutation of free radicals to compounds with much lower reactivity, (3) inhibition of catalase enzyme activity, (4) increased activity of antioxidant enzymes such as SOD, (5) chelation with pro-oxidative metals like iron and copper, and (6) increasing the effectiveness of other small antioxidants like tocopherols and ascorbic acid [208, 209]
Lancet Haematology In press
138 NAMPT has an important role in the tumorigenic microenvironment in leukemia, with eNAMPT playing an important role in macrophage differentiation to the M2 phenotype and polarization in tumorigenesis-associated macrophages
