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doi: 10.1016/S0741-8329(02)00229-X, PMID: [DOI] [PubMed] [Google Scholar] 69.Videla LA, Rodrigo R, Orellana M, Fernandez V, Tapia G, Quiones L, et al

Even if no adverse effects were detected, a larger study will be necessary in order to validate its clinical efficacy (Sufit et al., 2017)

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Combination therapy The scientific rationale for combining 5ARIs and 1 -AR antagonists is based on their different and complementary modes of action, that help in managing static and dynamic component responsible for of an enlarged prostate gland and symptoms of LUTS

Starting low and gradually increasing it will help to reduce the possibility of adverse effects