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Rawalpindi patients also frequently visit Islamabad-based clinics, given the proximity and wider availability of advanced treatment options

These substances are released when harmful microorganisms and bacteria are destroyed or die off

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For example, luteolin, a plant-derived flavonoid, downregulates the proinflammatory cytokines in macrophages and inhibits the production of nitric oxide and pro-inflammatory arachidonic acid by blocking the nuclear factor B (NF-B) signaling pathway (174)

These results showed that the artificial elevation of glutathione levels in tobacco leaves may significantly increase TMV resistance and suggested that in SA-deficient NahG plants glutathione may restore wild type levels of TMV resistance