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Tirzepatide is approved by the U.S

Histamine takes part in the pathophysiology of IBS and increases intestinal permeability and visceral hypersensitivity (82)

Depressive symptoms were linked to new-onset IR, as expressed by an increased Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) score [137], while dysosmia/dysgeusia was associated with low serum cortisol [207]

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