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The effects of insulin on pancreatic glucagon release have been proposed to be both paracrine and endocrine effects that are related to the direction of islet blood flow from -cells to -cells

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Typical for LCHAD deficiency is the increased risk for female heterozygous carriers to develop hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome and acute fatty liver of pregnancy (AFLP) [135, 136]

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doi: 10.1016/S2213-8587(21)00345-4 85