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This was consistent with other studies that showed that individual psychoactive alkaloids ( For the CSE of denicotinized cigarettes and nicotine, the effect on mice seems to be in conflict with the increased attraction compared to nicotine administration in the study by White et al., 2020), and the social and cultural factors ( The CPP test manifested the reinforcing effects of the rewarding stimulus (Figures 2A,B), which implied the possible promotion of DNC in the presence of nicotine

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We thank the participants of the MECHANISMS Study Concluding Conference in March 2021 for useful comments

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