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Nicotine can have antihistamine-like or mast-cell-modulating effects in certain contexts, which is why some people with MCAS or histamine intolerance are curious about it

(2) International Agency for Research on Cancer (IARC) (2012) A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts

At security, just pop it out for screening like you would with a laptop, TSA officers will visually inspect it

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