[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Bourque S.L., Dolinsky V.W., Dyck J.R.B., Davidge S.T
A study published in PMC examining chemical intolerance and mast cell activation found that alterations in the redox system, glutathione depletion, and pro-inflammatory cytokines interact to affect mast cell behavior. 13 When glutathione is depleted, oxidative stress increases, which can trigger mast cell activation through multiple pathways
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GPX7 and GPX8 also have cysteine as their active site and low glutathione peroxidase (GSH) activity, mainly due to the lack of domains bound to GSH