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This drives de novo blood vessel formation angiogenesis into injured tissue, which is a prerequisite for sustained repair and regeneration

This is further supported by the finding that ganglionic satellite cells can differentiate into Schwann cells (Sundaram et al., 2021)

DOI: 10.1007/s10561-016-9566-5

This allows your skin to build tolerance while still reaping the benefits of increased cell turnover. If your skin has adapted after a few weeks and you no longer have much irritation, you can increase your application to every other night or four to five times a week

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