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Research material data sheetCAS Number: 89030-95-5Molecular Formula: C14H24CuN6O4Molecular Weight: 403.93 g/molPurity: 99%Physical Form: lyophilized powderStorage: lyophilized form at -20 C, up to 24 months

Dot plots show cell viability and lipid-ROS in HC neutrophils (n = 7) cultured with 20% HC or SLE serum supplemented with -ME (10/50 M) for 16 hours

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

Increase reactive oxygen species (ROS) can promote lipid peroxidation

Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide