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10.1021/acsomega.2c05596 210 Nitecka-BuchtaA.BuchtaP.Tabeska-BosakowskaE.Walczyska-DragoK.BaronS

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CRPC closely associates with metastasis and rapid progression, typically exhibiting enhanced invasiveness and metastatic potential that sharply deteriorate prognosis

It implies controlled studies in human beings, with defined endpoints, that tell us whether a compound does what it is claimed to do