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Essentially, downregulation is where your body reduces the number of available CB1 receptors, thus dampening your high

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These cravings can be so powerful that they override rational thought processes and drive people to seek out substances despite negative consequences

[369] Food and Agriculture Organization of the United Nations, Statistics Division (FAOSTAT), Production, Countries by Commodity, Tobacco, Unmanufactured, 2012, August 2013, (accessed March 18, 2014)