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The reduced levels of these two neurotransmitter metabolites, combined with other potential biomarkers, might be used to predict disease severity and movement disability in MS, even though the mechanisms through which these monoamine metabolites reversely regulate the progression of MS and the activities of neurotransmitters remain unclear

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Because of its properties as an antioxidant, and its high intracellular concentration and wide distribution, its role as a potent defense mechanism against oxidative and electrophilic stress is well established

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