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Tight junction in the intestinal epithelium: Its association with diseases and regulation by phytochemicals

Archives of Dermatological Research , 301(4), 301-306.

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By screening small fragment-sized molecules (typically 120250 Da), chemical space can be effectively sampled using a substantially smaller number of compounds than through typical high-throughput screens (HTS) with bigger, lead-like molecules

350,351 When diseases advance, mitochondrial function deteriorates due to multiple factors, impairing the ability of mitochondria to generate ATP, increasing ROS production, and potentially enhancing mitochondrial membrane permeability, thus promoting inflammation and cell death