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126 A breed predisposition has been suggested for Doberman Pinschers (sulfonamides, amiodarone, diethylcarbamazine/oxibendazole) and Labrador Retrievers (carprofen), which may be a reflection of a genetic predisposition.21, 71, 73, 134, 137 Clinical Examination The spectrum of drug- and toxin-induced liver injury and, thus, the associated clinical presentation, can vary from subclinical hepatic injury with only increased serum liver enzyme activity, to severe liver damage manifested as ALF, or chronic end-stage liver disease

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