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Glycocalyx degradation after cardiac arrest and resuscitation in rats induces vascular endothelial adhesion factor (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), iNOS, and COX-2 expression, exacerbating neuronal loss, glial activation, and brain edema

These features aid in wound healing by minimizing oxidative stress, curbing inflammation, and enhancing angiogenesis (Figure 10)

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It had already fallen short of Novos internal weight-loss ambition in its first pivotal studythough that trial did meet endpoints