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Causes and Symptoms of B12 Deficiency Deficiency can arise from: Poor dietary intake Malabsorption issues (e.g., pernicious anemia, atrophic gastritis) Gastrointestinal surgeries or disorders (e.g., Crohns disease) Certain medications affecting stomach acid or absorption Symptoms of deficiency include fatigue, weakness, numbness or tingling in hands and feet, memory difficulties, mood changes, and in severe cases, neurological damage
Although some animals are very sensitive to biotin deficiency during pregnancy, a link between biotin deficiency and adverse effects in the mother and the developing fetus has not been observed in humans
The compound's mechanism as an NNMT (nicotinamide N-methyltransferase) inhibitor means it competes with dietary nicotinamide for the same metabolic pathway
